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There are hundreds of possible combinations for your materia setup in Final Fantasy 7, so it's hard to tell you all which ones are the best. Below is a compiled list of some of the better ones that we could think of. If you have one you'd like to add, .

Materia Combinations

Added Effect + Contain

Weapon: Attacks can cause a number of status effects such as Petrify, Confuse, Berserk or sometimes Paralyze to one or more enemies.
Armor: User becomes immune to Petrify, Confuse, Berserk and Paralysis.

Added Effect + Destruct

Weapon: If you're lucky, the weapon will deal a death-strike.
Armor: User becomes immune to instant death attacks like cross-scissor.

Added Effect + Mystify

Weapon: Some attacks can cause Berserk or Confuse to an opponent. If it's the former, then that's not too good. However, the power of confusion is very handy to have.
Armor: Gives the user immunity to berserk and confused statuses.

Added Effect + Poison

Weapon: Some attacks can poison an enemy.
Armor: User becomes immune to poinson attacks.

Added Effect + Seal

Weapon: Gives a very good chance of silencing or putting an enemy to sleep.
Armor: Grants the user immunity to Silence and Sleep.

Added Effect + Time

Weapon: Some attacks slow or even paralyze the enemy.
Armor: Gives the user immunity to Slow and Paralysis.

Added Effect + Transform

Weapon: Some attacks inflict Mini or Frog on the enemy.
Armor: Gives user immunity to Mini and Frog status.

Elemental + Elemental Summon (Ifrit, Shiva, Titan...)

Weapon: Adds element of summon (Fire for Ifrit, etc.) to weapon.
Armor: Grants user 50% resistance to summon element (resistance to Ice with Shiva, etc.).

Pre-Emptive + Materia

Anywhere: Depending on how lucky you are and how levelled your pre-emptive materia is, you'll sneak on the enemy(ies) and use the action associated with the linked materia.

Final Attack + Anything

Before your character dies, he / she / it will perform the action associated with the linked materia. For example:

Final Attack + Revive

Anywhere: The most basic combo for your character's dying act - He / she / it will cast the Revive spell on themselves right before dying.

HP Absorb + Damage Dealing Materia

Anywhere: The linked materia attack will restore some of your HP. For example:

HP Absorb + Knights of the Round

Anywhere: When KoTR attacks the enemy and they die (because they will), you will gain a lot of HP from it.

MP Absorb + Damage Dealing Materia

Anywhere: Same as HP Absorb + Anything, except it restores HP and not MP.

MP Turbo + Materia

Anywhere: This will use more MP to make the attached materia more powerful. For example:

MP Turbo + Knights of the Round

Anywhere: If your Magic stats is pretty high, this will cause each knight to deal up to 9999 damage. This means 130,000+ damage altogether.

Quadra Magic + Materia

Anywhere: The attached materia is performed 4 times, which can be handy if you have enough MP.

Counter + Deathblow

Anywhere: Counter attacks with a deathblow to that enemy.

Counter + Manipulate

Anywhere: Counter attacks by manipulating the attacking enemy.

Counter + Steal

Anywhere: Counter attacks by stealing from the enemy.

Counter + Morph

Anywhere: Counter attacks by trying to morph the enemy into an item.

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